Bioactive Compounds from Cuphea glutinosa Cham. & Schltdl.: Promising Effects on Antihypertensive Action

Bioactive Compounds from Cuphea glutinosa Cham. & Schltdl.: Promising Effects on Antihypertensive Action

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Abstract Cuphea glutinosa Cham.& Schltdl.(Lythraceae) is popularly used as antimicrobial, diuretic, anti-inflammatory, 15-eg2373cl and antihypertensive.This species features a great diversity of flavonoids, predominantly quercetin glycosides.This study aimed to investigate the chemical composition, and acute antihypertensive effect in vivo from C.

glutinosa leaf extracts on N(G)-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.The leaf extraction was conducted by exhaustive maceration and infusion.The chromatographic analyses were performed by ultra-fast liquid chromatography and photodiode array detection (UFLC-PDA).The assessment of antihypertensive activity in vivo was performed through the monitoring of the hemodynamic parameters.C.

glutinosa shows a predominance of quercetin glycosides, majority the miquelianin.The extracts displayed an antihypertensive effect in rats in doses of 2.5 to 50 mg/kg.These results suggest that the C.glutinosa extracts present antihypertensive potential by the presence of flavonoids and interactions among the phytoconstituents.

This research demonstrates that the extracts of C.glutinosa are flavonoid-rich and ratify the folk medicine usage of C.glutinosa as hypotensive and antihypertensive agents, in order to 5326058hx contribute to evidence-based traditional medicines.